A01
Tailor-made multifunctional polymers and nanoparticles with optimized compatibility between biodegradable core and encapsulated drug
A chemist works with liquid nitrogen.
By developing new degradable hydrophobic materials such as polyesterketals and polyesteramides, the project aims at designing these polymers to maximize the encapsulation efficiency for a given drug in a combined experimental and computational approach. Atomistic simulations, combined with machine learning approaches, will be used along with mesoscale simulations of real nanocarrier models for computationally efficient predictions of drug loading capacity, nanoparticle formation, encapsulation, and drug release.
Grafik Projekt A01
Graphic: C. Weber/FSU Jena
Prof. Dr. Ulrich S. Schubert
Image: Anne Günther (University of Jena)Prof. Dr. Ulrich S. Schubert
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de
Prof. Dr. Marek Sierka
Image: Prof. Dr. Marek SierkaProf. Dr. Marek Sierka
Otto Schott Institute of Materials Research (OSIM)
Friedrich Schiller University Jena
Löbdergraben 32
07743 Jena
Phone: +49 3641 9-47930
marek.sierka@uni-jena.de
Natalie Göppert
Image: Natalie GöppertNatalie Göppert
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
natalie.goeppert@uni-jena.de
Mingzhe Chi
Image: Mingzhe ChiMingzhe Chi
Otto Schott Institute of Materials Research (OSIM)
Friedrich Schiller University Jena
Löbdergraben 32
07743 Jena
Phone: +49 3641 9-47785
mingzhe.chi@uni-jena.de