A04
Spatial and temporal targeting of membrane-bound mPGES-1 and FLAP / 5-LO by dual inhibitors employing polymer-based nanocarriers
test tubes containing pink fuid
Project A04 aims at establishing novel and more effective drugs for resolving inflammation, specifically of dual inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase-activating protein (FLAP) or 5-lipoxygenase (5-LO). Improved bioavailability and target-specific delivery of the drug will be realized employing functionalized polymer-based particles as nanocarriers. Drug delivery at site will be investigated utilizing advanced fluorescence microscopy both in monocyte-derived macrophages and more complex biosystems.
Grafik Projekt A04
Prof. Dr. Oliver Werz
Prof. Dr. Oliver Werz
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49801
oliver.werz@uni-jena.de
Prof. Dr. Ulrich S. Schubert
Prof. Dr. Ulrich S. Schubert
Laboratory of Organic and Macromolecular Chemistry (IOMC)
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9-48200
ulrich.schubert@uni-jena.de
Prof. Dr. Christian Eggeling
Prof. Dr. Christian Eggeling
Institute for Applied Optics and Biophysics
Friedrich Schiller University Jena
Helmholtzweg 4
07743 Jena
Phone: +49 3641 9-47670
christian.eggeling@uni-jena.de
Philipp Dahlke
Philipp Dahlke
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
philipp.dahlke@uni-jena.de
Francisco Páez Larios
Francisco Páez Larios
Institute for Applied Optics and Biophysics
Friedrich Schiller University Jena
Philosophenweg 7
07743 Jena
Phone: 03641 9-47659
f.paez.larios@uni-jena.de