C02
Tailored delivery of anti-inflammatory natural drugs using polymer-based nanocarriers to prevent cytokine and eicosanoid storms in infectious inflammation
test tubes containing pink fuid
Anti-inflammatory drugs (novel 6BIGOE derivatives, AKBA, kadsurenin F, dexamethason) will be evaluated for interfering with cytokine and eicosanoid storms in infectious inflammation such as sepsis and Covid-19. They will be encapsulated under the application of new sustainable techniques in polymers with different stealth moieties and specific targeting strategies for the treatment of M1/M2 macrophages and SARS-CoV-2-infected epithelial cells. Using microfluidic biochips, a shell-less hen´s egg and a murine peritonitis model, the influence of environmental factors will be evaluated.
Grafik Projekt C02
Prof. Dr. Dagmar Fischer
Prof. Dr. Dagmar Fischer
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology and Biopharmacy
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstraße 4 (Haus 6)
91058 Erlangen
Phone: +49 9131 85-29552
dagmar.fischer@fau.de
Prof. Dr. Oliver Werz
Prof. Dr. Oliver Werz
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9-49801
oliver.werz@uni-jena.de
Vivien Bachmann
Vivien Bachmann
Institute of Pharmacy (IP)
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
vivien.bachmann@uni-jena.de
Jan Westhoff
Jan Westhoff
Department of Chemistry and Pharmacy
Division of Pharmaceutical Technology and Biopharmacy
Friedrich-Alexander-Universität Erlangen-Nürnberg
Cauerstraße 4 (Haus 6)
91058 Erlangen
Phone: +49 9131 85-29542
jan.westhoff@fau.de